• br Results br Discussion Our study provides clear

  2018-10-22

  

  Results Discussion Our study provides clear evidence for the continuous replacement of myocardial GSK1120212 by Sca1-positive CSCs, avoiding the potential problems associated with previously used labeling methods (Bergmann et al., 2009; Kajstura et al., 2010). Yet it is clear that our strateg

• The epigenetic modification of developmental genes

  2018-10-22

  

  The epigenetic modification of developmental genes, including alterations in DNA methylation, histone modifications, PcG, and non-coding RNA expression, which are passed on through successive cell divisions, has been suggested as one of the major mechanisms determining the fate of NSPCs (Mohamed Ari

• A potent methodology was recently developed to generate a

  2018-10-22

  

  A potent methodology was recently developed to generate a highly enriched population of floor-plate-derived midbrain lineage ESC-mDA and iPSC-mDA neurons sufficient to treat the large PD patient population (Kriks et al., 2011). Cellular Dynamics International made a critical translational advancemen

• Multiple enrichment schemes have been

  2018-10-22

  

  Multiple enrichment schemes have been devised to separate CMs from non-CMs by exploiting cell-specific physical and biological characteristics (Huber et al., 2007; Xu, 2012). Highly purified embryonic stem cell (ESC)-derived CMs populations have been isolated from ESC lines transduced with CM-specif

• Cancer stem progenitor cells CSPCs

  2018-10-20

  

  Cancer stem/progenitor Sapitinib manufacturer (CSPCs) are thought of as a confounding factor for carcinogenesis and cancer progression because of their capacity for unlimited self-renewal. Studies have shown that several glycoproteins, namely CD133 (Baba et al., 2009; Chen et al., 2014), CD117 (Luo

• The expansion and maturation of mature ECs and EPCs requires

  2018-10-20

  

  The expansion and maturation of mature ECs and EPCs requires the addition of pro-angiogenic growth factors such as VEGF. With regards the translation of cell-based therapies into clinic, it is of interest to avoid the expensive and controversial use of recombinant growth factors. The supplementation

• Although the concept of direct interference with

  2018-10-20

  

  Although the concept of direct interference with the genetic and molecular foundation of cardiac Concanamycin A is simple and elegant, myocardial gene transfer is difficult to achieve as a clinical reality. While the use of certain vectors ensures durable release of VEGF without genome integration,

• In the parenchymal niche found in

  2018-10-20

  

  In the parenchymal-niche found in the adult anterior lobe, SOX2-positive Phos-tag were more densely connected to each other than in the MCL-niche, and formed dense cell clusters by E-cadherin (Fig. 1). We previously demonstrated that CAR and ephrin-B2 specifically localize at the apical cell membra

• Previous studies describing antagonism between HIF

  2018-10-20

  

  Previous studies describing antagonism between HIF and v-Myc avian myelocytomatosis viral oncogene homolog (MYC) were mostly in the context of cancer, and the roles of HIF1α and HIF2α were determined to be distinct. HIF1α induced carboxypeptidase arrest by functionally counteracting MYC through p21

• Previously our group has isolated human embryonic stem

  2018-10-20

  

  Previously, our group has isolated human embryonic stem procyanidin b2 (ESCs) whose pluripotent state is maintained in vitro by exogenous growth factor signaling, particularly fibroblast growth factor (FGF), insulin or insulin-like growth factor, and transforming growth factor (Bendall et al., 2007;

• Recently several clinical trials of stem cell

  2018-10-20

  

  Recently, several clinical trials of stem-cell-based therapy for SCI using either human NS/PCs (Cummings et al., 2005; Salazar et al., 2010) or human ESC-derived OPCs (Strauss, 2010) have been initiated. Compared with these stem cells, iPSCs raise fewer ethical concerns in certain countries (Nori et

• br Experimental Procedures br Author

  2018-10-20

  

  Experimental Procedures Author Contributions Acknowledgments Introduction Since their discovery and isolation in 1998, human embryonic stem cytokine inhibitors (hESCs) have been considered a potentially valuable tool for generating replacement cells for therapeutic purposes (Lanza et al

• br Specification of germ cells in humans

  2018-10-20

  

  Specification of germ cells in humans The earliest identification of PGCs in the yolk sac was made by Fuss using transmission electron microscopy (TEM) during week 3 of life (Fig. 1). This work revealed that human PGCs are large spherical cells located amongst the smaller cells of the yolk sac en

• br Experimental Procedures br Author Contributions br Acknow

  2018-10-20

  

  Experimental Procedures Author Contributions Acknowledgments Introduction MicroRNAs (miRNAs) are short, endogenous, non-coding RNAs that repress gene expression post-transcriptionally by destabilizing and/or repressing translation of target mRNAs. In the canonical biogenesis pathway, pri

• br Experimental Procedures br Author Contributions br Acknow

  2018-10-20

  

  Experimental Procedures Author Contributions Acknowledgments B.Z. was supported by an NYSTEM post-doctoral training fellowship, The SKI Stem Cell Research Facility is supported by NYSTEM grants C029153 and C024175 and The Starr Foundation. The work was further supported in part by NIH/NCI g

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