br Experimental Procedures br Author

2018-10-20

Experimental Procedures Author Contributions Acknowledgments Introduction Since their discovery and isolation in 1998, human embryonic stem cytokine inhibitors (hESCs) have been considered a potentially valuable tool for generating replacement cells for therapeutic purposes (Lanza et al

br Specification of germ cells in humans

2018-10-20

Specification of germ cells in humans The earliest identification of PGCs in the yolk sac was made by Fuss using transmission electron microscopy (TEM) during week 3 of life (Fig. 1). This work revealed that human PGCs are large spherical cells located amongst the smaller cells of the yolk sac en

br Experimental Procedures br Author Contributions br Acknow

2018-10-20

Experimental Procedures Author Contributions Acknowledgments Introduction MicroRNAs (miRNAs) are short, endogenous, non-coding RNAs that repress gene expression post-transcriptionally by destabilizing and/or repressing translation of target mRNAs. In the canonical biogenesis pathway, pri

br Experimental Procedures br Author Contributions br Acknow

2018-10-20

Experimental Procedures Author Contributions Acknowledgments B.Z. was supported by an NYSTEM post-doctoral training fellowship, The SKI Stem Cell Research Facility is supported by NYSTEM grants C029153 and C024175 and The Starr Foundation. The work was further supported in part by NIH/NCI g

br Results br Discussion We report the development of

2018-10-20

Results Discussion We report the development of a method to generate and proliferate iCx26GJCs from mouse iPSCs for use as a disease model and in inner-ear cell therapies targeting GJB2-related hearing loss, the most frequent type of hereditary deafness worldwide. Our induction method until da

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2018-07-29