• The progression of a GBM depends on invasive

  2018-11-09

  

  The progression of a GBM depends on invasive growth marked by mesenchymal cell features. It therefore remains a critical priority to expand our knowledge of how the mesenchymal features are modulated. We have employed aSICS as an integrative modeling method to identify regulators of cancer subtypes.

• Glucose stimulated insulin secretion GSIS from pancreatic ce

  2018-11-09

  

  Glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells is biphasic, and suppression of the first-phase GSIS is one of the most characteristic findings of β-cell dysfunction in type 2 diabetes (). Consistently, decreased early insulin response is associated with post-prandial hyperglycem

• Identifying New Targets in Duchenne Muscular Dystrophy

  2018-11-09

  

  Identifying New Targets in Duchenne Muscular Dystrophy (DMD) Increasing our understanding of the pathophysiological mechanisms that manifest in DMD patients offers the opportunity to identify new pharmacological targets. Dominic Wells and Thomas Voit, University of London, provided insights into th

• br Methods br Results br Discussion br Conclusion br Conflic

  2018-11-09

  

  Methods Results Discussion Conclusion Conflicts of interest Acknowledgements Introduction Cross-sectional and longitudinal structural magnetic resonance imaging (MRI) studies have demonstrated that the human brain undergoes significant development during adolescence (Gogtay et a

• Age related changes in resting state networks in utero remai

  2018-11-09

  

  Age-related changes in resting-state networks in utero remain unclear. We obtained cross-sectional rs-fMRI data from 39 fetuses between 24 and 38 weeks postconceptual age to examine patterns of connectivity across ten functionally integrated ICNs. Following prior work in neonates (Smyser et al., 201

• br Methods br Results br Discussion

  2018-11-09

  

  Methods Results Discussion The plurals-in-compounds effect has received considerable attention in the psycholinguistic literature and has played a crucial role in more general debates in cognitive science concerning the role of grammar in language processing and development (e.g., McClellan

• However a growing number of

  2018-11-09

  

  However, a growing number of investigations are starting to paint a different picture . Explicitly learnt motor sequences seem to profit from sleep, but not implicitly learnt ones . When explicit motor sequences were further examined, it has been shown that their spatial representation is strengthen

• Introduction Larger application areas of Photonic Crystal Fi

  2018-11-09

  

  Introduction Larger application areas of Photonic Crystal Fiber (PCF) technologies have attracted much attention in recent years. PCFs have started a new era overcoming many limitations of conventional optical fiber. In the history of optical technology, PCFs have added new BMS-754807 through desi

• br Materials and methods br Results br

  2018-11-08

  

  Materials and methods Results Discussion Obesity results when caloric intake exceeds energy expenditure, with an increase in adipocyte size or adipocyte number (Bjorntorp, 1974; Faust et al., 1978; Johnson et al., 1971, 1978; Yu et al., 1997). In the context of adipogenesis, development app

• Human iPSC lines are usually

  2018-11-08

  

  Human iPSC lines are usually produced from fibroblasts isolated from skin biopsies, a traumatic invasive procedure demanding local anesthesia and medical follow-up. Hair follicle (HF) plucking, however, is simple, painless and a non-invasive alternative procedure. In the genuine study demonstrating

• However when we started this

  2018-11-08

  

  However, when we started this work, the data from the zebrafish and mouse studies had just been released, and a strategy to induce hematopoiesis in a stem cell population that could be obtained in very large numbers in the autologous setting seemed feasible, and with potentially huge implications in

• Due to the limited numbers of PGCs

  2018-11-08

  

  Due to the limited numbers of PGCs in mouse embryos, it is difficult to dissect the molecular mechanisms of early germ cell development. Recently, using ESC in vitro differentiation models, a number of studies demonstrated that Dazl, Blimp1, Lin28, and possibly Rhox6/Psx1, participated in PGC format

• OCT NANOG and THY are referred

  2018-11-08

  

  OCT4, NANOG, and THY1 are referred to as stem cell pluripotency markers. NANOG is expressed in porcine male germ cells, but OCT4 is not expressed in gonocytes of neonatal testes (Goel et al., 2008). However, OCT4 expression is detected in 2week cultures of PGP9.5 positive porcine spermatogonia from

• Herein we show that NEHUCB CD cell therapy accelerates wound

  2018-11-08

  

  Herein, we show that NEHUCB-CD34+ cell therapy accelerates wound closure in NOD/SCID mice, consistent with previous findings (Barcelos et al., 2009; Kim et al., 2010; Sivan-Loukianova et al., 2003). We used immunocompromised NOD/SCID mice for this study, as this mouse model is often used for human c

• An important concern regarding stem cell based therapies is

  2018-11-08

  

  An important concern regarding stem cell based therapies is the potential for unwanted cell growth. In a previous study we showed that the TheraCyte encapsulation device is durable enough to withstand freezing without evidence of cell escape, suggesting that once Exendin-3 (9-39) amide are sealed in

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