• br Materials and methods br Results br

  2018-11-08

  

  Materials and methods Results Discussion Obesity results when caloric intake exceeds energy expenditure, with an increase in adipocyte size or adipocyte number (Bjorntorp, 1974; Faust et al., 1978; Johnson et al., 1971, 1978; Yu et al., 1997). In the context of adipogenesis, development app

• Human iPSC lines are usually

  2018-11-08

  

  Human iPSC lines are usually produced from fibroblasts isolated from skin biopsies, a traumatic invasive procedure demanding local anesthesia and medical follow-up. Hair follicle (HF) plucking, however, is simple, painless and a non-invasive alternative procedure. In the genuine study demonstrating

• However when we started this

  2018-11-08

  

  However, when we started this work, the data from the zebrafish and mouse studies had just been released, and a strategy to induce hematopoiesis in a stem cell population that could be obtained in very large numbers in the autologous setting seemed feasible, and with potentially huge implications in

• Due to the limited numbers of PGCs

  2018-11-08

  

  Due to the limited numbers of PGCs in mouse embryos, it is difficult to dissect the molecular mechanisms of early germ cell development. Recently, using ESC in vitro differentiation models, a number of studies demonstrated that Dazl, Blimp1, Lin28, and possibly Rhox6/Psx1, participated in PGC format

• OCT NANOG and THY are referred

  2018-11-08

  

  OCT4, NANOG, and THY1 are referred to as stem cell pluripotency markers. NANOG is expressed in porcine male germ cells, but OCT4 is not expressed in gonocytes of neonatal testes (Goel et al., 2008). However, OCT4 expression is detected in 2week cultures of PGP9.5 positive porcine spermatogonia from

• Herein we show that NEHUCB CD cell therapy accelerates wound

  2018-11-08

  

  Herein, we show that NEHUCB-CD34+ cell therapy accelerates wound closure in NOD/SCID mice, consistent with previous findings (Barcelos et al., 2009; Kim et al., 2010; Sivan-Loukianova et al., 2003). We used immunocompromised NOD/SCID mice for this study, as this mouse model is often used for human c

• An important concern regarding stem cell based therapies is

  2018-11-08

  

  An important concern regarding stem cell based therapies is the potential for unwanted cell growth. In a previous study we showed that the TheraCyte encapsulation device is durable enough to withstand freezing without evidence of cell escape, suggesting that once Exendin-3 (9-39) amide are sealed in

• br DNA fingerprinting analysis The target regions of genomic

  2018-11-08

  

  DNA fingerprinting analysis The target regions of genomic DNA were amplified by Polymerase chain reaction (PCR). The PCR was carried out using a Thermocycler type PTC100 (MJ Research Inc) for 35cycles and each cycle contained 96°C for 30s, 56°C for 30s and 72°C for 30s. The following primer seque

• Cell adhesion molecules CAMs are transmembrane proteins that

  2018-11-08

  

  Cell adhesion molecules (CAMs) are transmembrane proteins that are responsible for mediating adhesion of cells to other cells and/or the extracellular matrix via their extracellular domains, while their intracellular domain interacts with the cytoskeleton. Thus, CAMs provide a direct link between th

• br Material and methods br Acknowledgement We thank Jane Hag

  2018-11-08

  

  Material and methods Acknowledgement We thank Jane Hagelskjær Knudsen, Christian Knudsen, and Bettina Hansen for excellent technical assistance. This project was supported by Aarhus University and partially by the Lundbeck Foundation (R151-2013-14439) and Danish Council for Independent Researc

• Another remarkable observation of this study

  2018-11-08

  

  Another remarkable observation of this study is that ASCL1-iN 4 mu are exclusively excitatory. This is surprising, because ASCL1 is not typically associated with the excitatory neuronal lineage during neural development (Bertrand et al., 2002; Fode et al., 2000; Guillemot et al., 1993; Johnson et a

• However it is likely that

  2018-11-08

  

  However, it is likely that, in addition to PU.1, other TFs participate in the initiation of the establishment of pre-existing enhancers and the activation of de novo enhancers. Thus, C/EBPα sites also were enriched for the RUNX motif, in line with the finding that during myelopoiesis Runx1 binds tra

• Nishi et al a b

  2018-11-08

  

  Nishi et al. (2014a, 2014b) have developed a method of inducing cancer stem-like purchase KN-93 (CSCs) through the reprogramming and partial differentiation of the immortalized but otherwise normal MCF10A human mammary epithelial cell line. To experimentally test our computational model of oncometa

• Thematic synthesis was used to identify important

  2018-11-07

  

  Thematic synthesis was used to identify important and recurrent themes (conducted in 2015) (Thomas & Harden, 2008). This method was developed based on the qualitative analytical technique ‘thematic analysis’ and borrows from traditional systematic review methods. It was developed with the aim that t

• As regards the tax problem there

  2018-11-07

  

  As regards the tax problem, there are two distinct types of variables. The impact of each input X on tax collection y depends on the magnitude of the coefficient β, which indicates whether these variables expand or contract the frontier, i.e., whether they increase or decrease the municipal tax coll

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