• For a physiologically relevant interaction

  2019-09-04

  

  For a physiologically relevant interaction, ligand and receptor have to be expressed in the same place. Collagen II is found primarily in cartilage. DDR2 is expressed in proliferating chondrocytes in vivo, and its staining pattern in tibial growth plates is similar to that of collagen II. In additio

• RNA sequencing RNA seq is a particularly effective technolog

  2019-09-04

  

  RNA-sequencing (RNA-seq) is a particularly effective technology for gene discovery in a given process, especially in non-model species for which reference genome sequences are not available. Although the major application of RNA-seq analyses is the identification of differentially expressed genes (D

• Proteases as multifunctional enzymes play key roles

  2019-09-04

  

  Proteases, as multifunctional enzymes, play key roles in controlling a wide variety of cellular and extracellular processes in plants and animals, including protein degradation and processing, germination, complement activation, inflammation, responses to environmental stimuli, senescence and so on.

• The CysLT receptor antagonist BayCysLT RA significantly supp

  2019-09-04

  

  The CysLT2 receptor antagonist BayCysLT2RA significantly suppressed multiple antigen challenge-induced infiltration of eosinophils and mononuclear o6 methylguanine methyltransferase into the lung, indicating that CysLT2 receptor activation is involved in leukocyte migration. In contrast to the prese

• Previously to detect CDKL activity we used a radioactive pho

  2019-09-04

  

  Previously, to detect CDKL5 activity, we used a radioactive phosphorylation assay with amphiphysin 1 protein as a substrate [,,]. However, it is necessary to establish a safe and rapid method for analyzing CDKL5 mutant activity. Here, we report a new method for investigating autophosphorylation acti

• A previous report showed that the transfer of the CSF

  2019-09-04

  

  A previous report showed that the transfer of the CSF1 gene into tumor erk inhibitor induced TAM infiltration into syngeneic BALB/c mice. High expressions of CSF-1 and CSF-1R in tumor and stromal cells and a high TAM density are known to be correlated with poor prognoses in many cancer types. CSF-1

• Ligand binding RTK activation induces the endocytic internal

  2019-09-04

  

  Ligand binding (RTK activation) induces the endocytic internalization of RTKs, and this has been demonstrated for CSF-1R [15], [16], [17]. Endocytosed RTKs are targeted to the lysosome, which we and others have established to be dependent on ubiquitination via CBL-family and recognition by ESCRT com

• mlck and br Results br Discussion GPCRs recognize a

  2019-09-04

  

  Results Discussion GPCRs recognize a broad range of molecules with a vast chemical mlck and through different mechanisms. Our understanding of the recognition of lipid mediators by GPCRs primarily comes from the structural studies of receptors for lysophospholipids and endocannabinoids includ

• Although the presence of at

  2019-09-04

  

  Although the presence of at least one triple helix domain is typically the collagen signature, collagens are modular proteins composed of a succession of collagenous (COL) and non-collagenous domains (NC) that are both involved in collagen functions and in receptor binding. COL domains are linked by

• mass molarity calculator Investigations of mice lacking up t

  2019-09-03

  

  Investigations of mice lacking up to three CDKs identified the mitosis-regulating kinase CDK1 as the main essential component for the cell cycle, whereas ablation of other mass molarity calculator regulators such as CDK2, CDK4, or CDK6 did not result in defective proliferation 12, 13. Mouse models

• The full length human CPG protein is expressed

  2019-09-03

  

  The full-length human CPG2 protein is expressed in CNS tissue with the highest expression in the neocortex, hippocampus and striatum, consistent with mRNA localization patterns of the rat Cpg2 homolog (Cottrell et al., 2004). In the rat, the CPG2 protein localizes primarily to the postsynaptic endoc

• There was a measurable worsening but not a

  2019-09-03

  

  There was a measurable worsening, but not a statistically significant change in the baseline and follow-up best ear hearing scores, where the mean worsening change was 11.9 dB (95% CI: −1.11–24.86, p-value = 0.070). However, of the 16 patients, 14 (87.5%) were found to have clinically significant wo

• hepititis b Many PIM inhibitors have been reported to date h

  2019-09-03

  

  Many PIM inhibitors have been reported to date [7], [8], [9] however, none of them has been marketed so far. SGI-1776 is a representative first-generation PIM inhibitor, which had been under clinical trials for leukemia and prostate cancer [10]. While most of the first-generation PIM inhibitors are

• br Acknowledgements This work was supported by

  2019-09-03

  

  Acknowledgements This work was supported by National Natural Science Foundation of China (31701807, 31572000) and Jiangsu Province Science Foundation for Youths (BK20170491). Introduction Two Cl− channels of the ClC family, ClC-K1 and ClC-K2 (or their human orthologs ClC-Ka and ClC-Kb, respec

• br Acknowledgments br Significance The mechanisms underlying

  2019-09-03

  

  Acknowledgments Significance The mechanisms underlying the adverse effects of Epo-stimulating agents on the reduced survival of cancer patients are not well understood. Here, we identified EphB4 as an alternative Epo receptor, which triggers Src/Stat3 signaling via EphB4. We also showed that r

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