• Several highly selective COX inhibitors coxibs have been

  2019-07-02

  

  Several highly selective COX-2 inhibitors (coxibs) have been reported and marketed [6], including celecoxib [7] and etoricoxib [8] (Fig. 1). Even though these drugs produce less ulceration than conventional NSAIDs, coxibs still produce significant gastric and cardiovascular side effects due to the d

• Research done thus far supports the hypothesis that MPA

  2019-07-02

  

  Research done thus far supports the hypothesis that MPA has detrimental effects on cognition, alone and in combination with estrogen; there are other FDA-approved progestogens that satisfy the uterus opposing effects that have not been cognitively profiled. An important goal to aid women\'s health i

• br Conclusions ERK and its phosphorylation

  2019-07-02

  

  Conclusions ERK 1/2 and its phosphorylation plays an essential role in the hippocampus and can be triggered by both ROS accumulation and excessive Ca2+. DBP exposure can also affect the production of ROS and Ca2+ in the hippocampus. The question therefore arises as to whether the cell injury or a

• Recent studies have shown that the extracellular regulated p

  2019-07-02

  

  Recent studies have shown that the extracellular regulated protein kinase 1 and 2 (ERK1 and ERK2), commonly referred to collectively as ERK 1/2, are members of the mitogen-activated protein kinase (MAPK) family. This family of kinases transport signals from the surface of the cell to the nucleus, th

• Exposure to UV instead of DMBA also produced

  2019-07-02

  

  Exposure to UV instead of DMBA also produced a sloughing and angiogenic response in transgenic, but not WT, mice, indicating that the epidermis of the BK5.EP4 mice has a much lower apoptosis threshold than WT mice, as suggested by others (Chun and Langenbach, 2007). Overall, these studies suggest th

• The Mexico City Policy is

  2019-07-01

  

  The Mexico City Policy is also flawed on evidentiary and public health grounds. A 2011 study found that enforcement of the Mexico City Policy by the George W Bush administration led to an increase in abortion rates in sub-Saharan Africa, probably because of decreased contraception access and increa

• MiR a rs is situated

  2019-07-01

  

  MiR-196a2 rs11614913 is situated in the 3′ passenger strand mature sequence of miR-196a2. The C to T mutation of the rs11614913 SNP, which was located in the stem region of an miR-196a-2 precursor, leads to a change from a G:C to a G:U mismatch. A previous study has shown that miR-196a2 rs11614913 c

• Since the first description of

  2019-07-01

  

  Since the first description of epicardial VT ablation with percutaneous subxiphoid access in 1996, epicardial mapping and ablation have been widely performed for the treatment of scar-related VT [55]. Svenson et al. reported that phospholipase c inhibitor epicardial VT circuits are particularly com

• br Bisphosphonate use and breast cancer risk

  2019-07-01

  

  Bisphosphonate use and breast cancer risk BPs are commonly used in the management of postmenopausal osteoporosis. They consist of two phosphate groups, which give them a high affinity to bone. They attach to bone at exposed calcium hydroxyapatite binding sites, which are most accessible at sites

• Introduction Benign tumours of the bone consist of a wide

  2019-07-01

  

  Introduction Benign tumours of the bone consist of a wide variety of different neoplasms. These tumours vary in terms of incidence, clinical presentation and require a diverse array of therapeutic options. The incidence of benign bone tumours is debated due to their often asymptomatic presentation

• We conducted a retrospective analysis to

  2019-07-01

  

  We conducted a retrospective analysis to compare a BMD-alone strategy, versus BMD+FRAX® and BMD+FRAX®+TBS screening strategies. To our knowledge, this constitutes the first study to assess the relative contributions of FRAX® and TBS. In our cohort, FRAX®+BMD identified 9 (9%) additional patients at

• br Discussion The rate of ERP in young healthy men

  2019-07-01

  

  Discussion The rate of ERP in young, healthy men in northeastern Thailand was 10.3%. This is higher than the rate reported in the US (3.3–6.1%) [12]. In the US report, the mean age of the study population was 45 years, which was older than the age of subjects in our study. Another report from the

• The appearance of J wave or ER is now recognized

  2019-07-01

  

  The appearance of J wave or ER is now recognized to predispose to the development of arrhythmogenesis when associated with other cardiac disorders, such as ischemia, Exendin-3 (9-39) amide structure failure, and hypothermia. The J wave might predict prognosis of cardiac events in various heart dise

• We would like to also clarify that we do not

  2019-07-01

  

  We would like to also clarify that we do not underestimate the CIs in our study through the assumption that GDP was observed independently for every child in the survey. The multilevel design and clustering of standard errors at the survey level accounts for the fact that GDP is not observed indepen

• La representaci n colectiva de

  2019-07-01

  

  La representación colectiva de los indígenas se caracteriza por el tono apologético, idealizado, en el que el uso abundante de los superlativos contribuye RG7112 resaltar hiperbólicamente la naturaleza pacífica del nativo como “buen salvaje”: Siguiendo el esquema de las oposiciones binarias, Las Ca

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